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    1. Cell Biology
    2. Neuroscience

    Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles

    Jeremy Leitz, Ege T Kavalali
    Spontaneous fusion of vesicles at synapses is regulated independently of fusion triggered by action potentials, adding to evidence that the two types of fusion have distinct functions.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells

    Tony Ly et al.
    Quantitative analysis of protein and mRNA expression across a minimally perturbed cell cycle in human myeloid cells has identified myeloid-specific and cell cycle-regulated gene expression, including examples of isoform- and phosphorylation-specific regulation, with all data made available in a searchable, online database.
    1. Immunology and Inflammation

    Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation

    Yong Miao et al.
    Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.
    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis

    Blessy Paul et al.
    Chlamydia hijacks membrane trafficking proteins of the human host via the cytoplasmic domain of a secreted transmembrane protein.
    1. Microbiology and Infectious Disease

    Insect endosymbiont proliferation is limited by lipid availability

    Jeremy K Herren et al.
    The endosymbiont Spiroplasma can only proliferate if it can acquire sufficient hemolymph lipids from its insect host.
    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit

    Julia Hatzold et al.
    A Na,K-ATPase beta subunit can suppress basal cell carcinogenesis either via its osmoregulatory function to avoid hypotonic stress, or by promoting epithelial polarity and adhesiveness of basal keratinocytes from the overlying outer layer.
    1. Cell Biology

    YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

    Gisela Schimmack et al.
    The deubiquitinating enzyme YOD1 binds to the E3 ligase TRAF6 to counteract p62/sequestosome1 mediated pro-inflammatory NF-κB signaling in response to interleukin-1.
    1. Neuroscience
    2. Developmental Biology and Stem Cells

    Neuroendocrine modulation sustains the C. elegans forward motor state

    Maria A Lim et al.
    RID is a descending peptidergic neuron that sustains the forward motor state.
    1. Neuroscience

    Vocalization–whisking coordination and multisensory integration of social signals in rat auditory cortex

    Rajnish P Rao et al.
    Snout-to-snout contact modulates the response of rat auditory cortex to calls from other animals, indicating that the multisensory nature of social interaction is directly represented in the rat brain.