6 results found
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan et al.
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

    Mitsuhiro Endoh et al.
    PCGF6 links sequence specific target recognition by the MAX/MGA transcription factor complex to PRC1 (polycomb repressive complex 1) -dependent transcriptional silencing of germ cell-specific genes in mouse pluripotent stem cells.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice

    Mina L Kojima et al.
    The switch from mitotic cell cycles to the one meiotic cell cycle in each generation is triggered through dramatic upregulation of a broad gene expression program by transcriptional regulator STRA8.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

    Min Jung et al.
    A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

    Simon Mysling et al.
    Intravascular triglyceride hydrolysis by lipoprotein lipase is crucial for delivering lipid nutrients to vital tissues, such as the heart, skeletal muscle, and adipose tissue.
    1. Cancer Biology
    2. Cell Biology

    Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells

    Michiel van Veen et al.
    GDE3 is a transmembrane GPI-specific phospholipase C that sheds the urokinase receptor (uPAR) from the cell surface resulting in loss of uPAR function in breast cancer cells and reduced tumor growth.

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