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Diversification of human pacemaker subpopulations is directed by WNT and TGFβ signaling.

SIRT4 regulates cellular communication network factor 2 expression through U2 small nuclear RNA auxiliary factor 2-mediated pre-mRNA splicing, presenting a potential therapeutic target for kidney fibrosis.

Inhibition of a single fibroblast-associated transcription factor, namely Paired-related Homeobox Protein 1 (PRRX1), is sufficient to dampen lung fibrogenesis.

The membrane type I-matrix metalloproteinase is essential for the release of collagen fibrils from plasma membrane fibripositors, which is required for the transition from embryonic to postnatal tendon development.

Anomalous expression of the testis protein ZNF165 in cancer cells promotes assembly of a neomorphic transcriptional complex that modulates transcription of TGFβ target genes to support tumor cell survival.

A functional genetic variant, rs1690789, affects susceptibility to emphysema by altering TGFB2 expression in human lung fibroblasts.

Tumor-growth-factor-beta signaling helps cancer cells to evolve and become resistant to drugs by down-regulating accurate DNA repair.

Stromal cell levels and localization of active α₅β₁-integrin are regulated by desmoplastic extracellular matrix control of α_vβ₅-integrin signaling, and predict clinical outcomes for pancreatic and renal cancer patients.

Corefucosylation contributes to the maintenance of the articular cartilage phenotype and depletion of FUT8 inhibits recovery from cartilage damage and promotes cartilage degeneration.

C-terminal phosphorylation of the lipid phosphatase PTEN drives a reduction in membrane affinity and leads to a more compact conformation that involves a C2 domain-tail interaction.