454 results found
    1. Stem Cells and Regenerative Medicine

    Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

    Mi-Sun Lee et al.
    Tgfb3 inhibits Muller glial cell reprogramming and drives Muller cell quiescence in the injured zebrafish retina, thereby inhibiting retina regeneration.
    1. Genetics and Genomics

    Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts

    Margaret M Parker et al.
    A functional genetic variant, rs1690789, affects susceptibility to emphysema by altering TGFB2 expression in human lung fibroblasts.
    1. Immunology and Inflammation

    TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

    Marije Baas et al.
    The interplay between the cytokine TGFβ and the PD-1/PD-L1 pathway promotes CD8+ T cell anergy and tolerance towards transplanted tissues.
    1. Cancer Biology

    The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

    Zane A Gibbs et al.
    Anomalous expression of the testis protein ZNF165 in cancer cells promotes assembly of a neomorphic transcriptional complex that modulates transcription of TGFβ target genes to support tumor cell survival.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

    Deepak A Kaji et al.
    TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.
    1. Immunology and Inflammation
    2. Neuroscience

    Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization

    Wenxin Ma et al.
    TGFβ signaling to retinal microglia is central to the regulation of neuroinflammatory responses relevant to age-related macular degeneration (AMD), a leading cause of blindness in the developed world.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis

    Xiaodan Ji et al.
    Transcription elongation by the elongation factor P-TEFb promotes the epithelial–mesenchymal transition and metastasis of breast cancer cells, implicating inhibition of this factor as a potential treatment for the late stages of this cancer.
    1. Cell Biology
    2. Developmental Biology

    Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

    Barak Blum et al.
    Loss of mature β cell identity in diabetes can be prevented and rescued by small molecule inhibitors of the TGFβ pathway.
    1. Cell Biology
    2. Developmental Biology

    Tgfβ signaling is critical for maintenance of the tendon cell fate

    Guak-Kim Tan et al.
    Conditional deletion of TGFβ signaling results in tenocyte dedifferentiation in vivo demonstrating a key role for TGFβ signaling in the maintenance of the tendon cell fate.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

    Anassuya Ramachandran et al.
    SMAD1/5 signaling is essential for the full transforming growth factor β (TGF-β)-induced transcriptional program and physiological responses and is induced via a novel receptor activation mechanism, involving two distinct type I receptors.

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