776 results found
    1. Medicine
    2. Microbiology and Infectious Disease

    Mucosal effects of tenofovir 1% gel

    Florian Hladik, Adam Burgener ... Ian McGowan
    Mucosal application of the anti-retroviral drug tenofovir, which is intended to prevent HIV transmission, has many off-target effects on the mucosa itself.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Biophysical clocks face a trade-off between internal and external noise resistance

    Weerapat Pittayakanchit, Zhiyue Lu ... Arvind Murugan
    Molecular clocks that are robust to external fluctuations are vulnerable to internal fluctuations and vice versa.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Conformist social learning leads to self-organised prevention against adverse bias in risky decision making

    Wataru Toyokawa, Wolfgang Gaissmaier
    Mathematical modelling and large-scale online experiments revealed that learning from others can induce 'smarter' decisions even when most individuals are biased towards adverse risk aversion.
    1. Biochemistry and Chemical Biology

    SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

    Pascal Demange, Etienne Joly ... Sébastien Britton
    Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.
    1. Developmental Biology

    Axon tension regulates fasciculation/defasciculation through the control of axon shaft zippering

    Daniel Šmít, Coralie Fouquet ... Alain Trembleau
    Competition between adhesive and tensile forces regulates axon fasciculation, thus introducing a new role of mechanical tension in the development of neural networks.
    1. Developmental Biology
    2. Genetics and Genomics

    A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions

    Uri Seroussi, Andrew Lugowski ... Julie M Claycomb
    Systematically studying the expression, small RNA-binding partners, and loss-of-function phenotypes of all 19 Argonautes uncovers how small RNA regulatory pathways function and interact in Caenorhabditis elegans, a long-standing model for small RNA biology and RNAi.
    1. Biochemistry and Chemical Biology

    Regulated mRNA recruitment in dinoflagellates is reflected in hyper-variable mRNA spliced leaders and novel eIF4Es

    Grant D. Jones, Ernest P. Williams ... Rosemary Jagus
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Imaging microglia surveillance during sleep-wake cycles in freely behaving mice

    Xiaochun Gu, Zhong Zhao ... Heping Cheng
    Using long-term in vivo imaging with miniature two-photon microscopy, microglia surveillance is sleep state-dependent and stress-induced in freely behaving mice, regulated by the locus coeruleus-norepinephrine system and β2-adrenergic receptors signaling.
    1. Neuroscience

    Internally generated time in the rodent hippocampus is logarithmically compressed

    Rui Cao, John H Bladon ... Marc W Howard
    Receptive fields for time in the hippocampus, like receptive fields for retinal space and receptive fields for numerosity, obey the Weber-Fechner law.
    1. Developmental Biology

    Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation

    Satoshi Yamashita, Shuji Ishihara, François Graner
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete

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