Lateral gene transfer is unable to resist mutation accumulation in large genomes, leading to selective pressure for the origin of meiotic sex in the first eukaryotes.
Zoé Christenson Wick, Madison R Tetzlaff, Esther Krook-Magnuson
An intersectional genetic vector approach allows the identification and characterization of novel hippocampal inhibitory neurons with both broad local connectivity within CA1 and long-range projections to several extrahippocampal areas.
Trafficking of optogenetic tools to primary cilia using nanobodies allows to study cAMP signaling with spatial and temporal resolution independent of the cell body.
Xuemeng Zhang, Thomas Kampourakis ... Yin-Biao Sun
The Frank–Starling law of the heart and its underlying mechanism of length-dependent activation involve distinctive structural changes in both the thin and thick filaments of cardiac muscle cells.
A near-linear relationship between electrical stimulus duration and resultant joint torque in stick insects has been unveiled, enhancing control strategies in biohybrid robotics.
Katherine A Smith, Stephan Löser ... Rick M Maizels
Immune expulsion of helminth parasites is driven by two key pathways mediated by soluble cytokines ligating to the IL-4 and IL-25 receptors acting on innate effector cells throughout the course of infection.
Proteomics and metabolic modeling revealed that the 'knallgas' bacterium Cupriavidus necator utilizes only a fraction of its proteome and keeps large enzyme reserves as an adaption to variable environments.
Nick D Pokorzynski, Amanda J Brinkworth, Rey Carabeo
Analysis of the atypical tryptophan biosynthetic operon of Chlamydia trachomatis revealed the simultaneous regulation of transcriptional initiation and termination by an iron-dependent repressor, expanding known regulatory mechanisms of this pathway.
