The changes in shape of iridophores that underlie adult colour pattern formation in zebrafish depend on the levels of Tight Junction Protein 1a in these cells.

That early cortical neural progenitor divisions strictly require OCLN isoform expression is a paradigm shift in the functional consideration of this protein best known for promoting between-cell barrier functions.

Paracellular, trans-tight junction channels, which communicate between two extracellular compartments without crossing the plasma membrane, are a new class of ion channel with unitary behaviors similar to traditional transmembrane channels.

Proteins pivotal to epithelial polarization organize in separated clusters, simplifying the current view by showing that a small fraction of the many protein–protein interactions proposed are prominent in mature epithelia.

Organ and vessel-type-specific differences in endothelial cell barrier composition and properties uncover the distinct importance of the major tight junction protein Claudin5 in restricting agonist-induced leakage.

Super-resolution imaging uncovers sparse occludin vs. clustered ZO1/claudin-5 architecture, and claudin-5 arrangement compacting during blood-brain-barrier tight-junction (TJ) maturation in which TJs become first restrictive to large and later to small molecules.

The strain-transcendent receptor CD55 plays a distinct functional role relative to other known receptors for Plasmodium falciparum invasion of human erythrocytes, indicating it may present a vulnerable target for intervention.

An effector of AMPK is essential for the kinase and its pharmacological activators, including Metformin, to strengthen cell-cell junctions and preserve epithelial cell polarity and barrier functions in the face of energetic stress, as well as to suppress oncogenesis.

The pressure of fluid in the inner ear is controlled by opening of cellular valves in the endolymphatic sac to allow for regulated transepithelial fluid flow.

Hyperglycaemia increases influenza severity by damaging the pulmonary epithelial-endothelial barrier and increasing pulmonary oedema during Influenza A virus infection.