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    1. Neuroscience

    Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila

    Amicia D Elliott et al.
    The elementary units of a fruit fly behavioral sequence are described at single-muscle resolution and shown to exhibit variability that is subject to neuromodulatory regulation.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Development of antibacterial compounds that constrain evolutionary pathways to resistance

    Yanmin Zhang et al.
    Integrated multi-scale, multi-tool approach to design novel 'evolution drugs' which can delay the emergence of antibiotic resistance by constraining bacterial evolutionary escape strategies.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    AAV ablates neurogenesis in the adult murine hippocampus

    Stephen Johnston et al.
    Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Price equation captures the role of drug interactions and collateral effects in the evolution of multidrug resistance

    Erida Gjini, Kevin B Wood
    A simple mathematical model reveals that antibiotic interactions and collateral effects of evolution are inseparable drivers of multidrug resistance linked by the well-known Price equation from evolutionary theory.
    1. Cell Biology
    2. Developmental Biology

    SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

    Evelien Eenjes et al.
    The balance between SOX2 and SOX21 is evolutionary conserved and is important for cell fate decision during lung epithelium development and repair after damage.
    1. Cell Biology
    2. Developmental Biology

    Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

    Patricia Giselle Cipriani et al.
    Two novel LOTUS-domain proteins are core germ granule components that directly recruit Caenorhabditis elegans Vasa, regulate germ granule size and localization, and provide an organizational framework for ribonucleoprotein complexes.
    1. Neuroscience

    An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction

    Steven R Sando et al.
    By driving the localized contraction of subcellular muscle regions, a single motor neuron reverses the flow of material in the Caenorhabditis elegans pharynx, a neuromuscular pump, converting feeding into spitting.
    1. Neuroscience

    Value signals guide abstraction during learning

    Aurelio Cortese et al.
    Valuation of sensory information in the ventromedial prefrontal cortex plays a key function in constructing the abstract representations that guide complex behaviours.
    1. Epidemiology and Global Health

    Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset

    Ariel Karlinsky, Dmitry Kobak
    The World Mortality Dataset and paper is the largest dataset of all-cause mortality currently in existence for tracking mortality and excess mortality during the COVID-19 pandemic.
    1. Cell Biology
    2. Neuroscience

    Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

    Francois Singh et al.
    The most common Parkinson’s disease-associated mutation, LRRK2 G2019S, impairs mitophagy in clinically relevant cells within the mouse brain and this defect can be reversed using a novel LRRK2 inhibitor.