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Interactions between near but distinct (<1 mm) structures such as cortical layers in the rodent brain can be studied by a new micro-optical tool that is low-cost and capable of multilayer optical recordings, optogenetic stimulations, or both.

COVID-19 ‘excess mortality’ has been estimated for more than 100 countries and shows a dramatic death toll in many countries.

Microbial-sensing TLRs drive responses to the microbiota, while nucleic-acid sensing TLRs control responses to endogenous ligands, revealing novel regulation of B-1a responses through integrated BCR/TLR mediated activation.

Optogenetic activation of Rho GTPases provides spatiotemporal control over endothelial cell shape and enables control over endothelial barrier function by manipulating the cell-cell overlap with blue light.

Crucial functions of Toll signalling during dorsoventral axis formation might have evolved convergently in flies and crickets.

A novel approach together with a user-friendly web-based analytic tool, coined 'REAP', was proposed to improve the quantitative assessment of dose-response relationship and drug potency.

The epigenetic regulator TET1 is regulated by the nutrient-sensing enzyme OGT in vitro and in cells.

Imaging experiments reveal that some brain regions do not distinguish between actions performed using tools and those performed using the hands, while others represent these two types of action separately.

Playing a violent game for a few weeks did not alter neural and behavioral responses to the pain of others in inexperienced male gamers.

The NetPyNE software tool provides a framework to efficiently develop, simulate, optimize and analyze experimentally grounded neural models spanning the molecular, cellular and circuit scales.