1,135 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

    Sarah Louise Latty et al.
    The strength of Toll-like receptor signalling depends on the number and size of MyDDosomes formed as well as on how quickly these structures assemble.
    1. Cell Biology
    2. Immunology and Inflammation

    Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

    Xiao-Dong Li, Zhijian J Chen
    A pattern recognition receptor called toll-like receptor 13 detects pathogens in a manner that is different to that seen in other pathogen sensors.
    1. Cell Biology
    2. Immunology and Inflammation

    UNC93B1 mediates differential trafficking of endosomal TLRs

    Bettina L Lee et al.
    A transmembrane protein uses distinct mechanisms to regulate the movement of specific toll-like receptors-key immune system components involved in detecting pathogens-to their final locations inside cells.
    1. Immunology and Inflammation

    Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1

    Guo-Yun Chen et al.
    Sialoside-based pattern recognition by Siglecs directly regulates toll-like receptor signaling and a sialidase inhibitor protects against endotoxemia.
    1. Cell Biology

    Toll-like Receptors: Different routes to the same destination

    Kachiko Hayashi, Akiko Iwasaki
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    1. Microbiology and Infectious Disease
    2. Neuroscience

    Microbiota regulates visceral pain in the mouse

    Pauline Luczynski et al.
    Determining that microbiota-deficient mice have increased visceral pain, which can be reversed by restoring microbiota, may lead to novel microbial-based strategies for disorders associated with visceral pain.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

    Ayaka Ito et al.
    The cholesterol-sensing nuclear receptor LXR regulates inflammatory responses by altering the lipid composition of cell membranes.
    1. Cell Biology
    2. Immunology and Inflammation

    IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

    Hao Zhou et al.
    The stimulation of lipopolysaccharides induced nuclear localization of IRAK2 to facilitate nuclear export of a specific subset of inflammation-related messenger RNAs for translation in murine macrophages.
    1. Immunology and Inflammation

    Cancer: How the immune system spots tumors

    Yasutaka Okabe, Ruslan Medzhitov
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    1. Cell Biology
    2. Human Biology and Medicine

    Carcinogenesis: Targeting the link between late pregnancy and breast cancer

    Balabhadrapatruni VSK Chakravarthi, Sooryanarayana Varambally
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