1,688 results found
    1. Structural Biology and Molecular Biophysics

    N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

    Fang Tian et al.
    Spike protein of SARS-CoV-2 with mutation N501Y shows a faster association rate, slower dissociation rate, and higher binding probability and unbinding force to its human receptor protein ACE2, leading to higher transmission.
    1. Medicine

    Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

    Mieradilijiang Abudupataer et al.
    An aorta smooth muscle-on-a-chip model indicated that NOTCH1 insufficiency in HAoSMCs induced phenotypic switching from a contractile to a synthetic phenotype accompanied by an impairment of mitochondrial fusion, implying its potential role as a therapeutic target for BAV-TAA.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

    Zdravka Daneva et al.
    Endothelial pannexin 1-P2Y2 purinergic receptor-TRPV4 channel signaling, facilitated by caveolin-1, is a novel pathway for lowering pulmonary arterial pressure.
    1. Immunology and Inflammation

    Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells

    Anders Laustsen et al.
    Probing of various culture conditions leads to fundamental advances in ex vivo production of plasmacytoid dendritic cells for use in immunotherapy.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

    Arantxa Cebrian-Silla et al.
    Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Drosophila STING protein has a role in lipid metabolism

    Katarina Akhmetova et al.
    Drosophila STING protein, or stimulator of interferon genes, has a direct but previously unknown role in the lipid metabolism.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

    Giulia Bandini et al.
    The activity, localization, and essentiality of TbFUT1, together with its ability to complement Leishmania parasites lacking the homologous gene, suggest the presence of an uncommon and conserved mitochondrial fucosylation pathway required for kinetoplastid parasites viability.
    1. Medicine
    2. Neuroscience

    Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY

    Xiao Lv et al.
    PGE2/EP4 skeleton interoception regulates bone and fat metabolism via hypothalamic NPY.
    1. Physics of Living Systems

    Symmetry breaking meets multisite modification

    Vaidhiswaran Ramesh, J Krishnan
    Network symmetry represents a new vantage point for dissecting complex information processing characteristics in multisite modification, and the breaking of symmetry can confer ordering of modification and absolute concentration robustness.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

    Suhong Sun et al.
    Adult cochlear supporting cells (SCs) are plastic and respond to ectopic Ikzf2 and Atoh1, and hair cell damage by up-regulating HC and down-regulating their endogenous SC genes.

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