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    1. Ecology

    Countercurrent heat exchange and thermoregulation during blood-feeding in kissing bugs

    Chloé Lahondère, Teresita C Insausti ... Claudio R Lazzari
    A novel thermoregulatory mechanism in blood-sucking insects, vectors of human disease, is described using a functional-morphological approach.
    1. Medicine

    Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise

    Matthew Hancock, Anne D Hafstad ... Min Zhang
    Cardiomyocyte Nox4 is a crucial physiological mediator of Nrf2 activation during acute exercise, triggering an adaptive response that preserves redox balance, mitochondrial and cardiac function to support normal physical exercise.
    1. Ecology

    Vessel noise levels drive behavioural responses of humpback whales with implications for whale-watching

    Kate R Sprogis, Simone Videsen, Peter T Madsen
    Controlled exposure experiments reveal that underwater vessel noise level from a motorised vessel is an adequate driver of behavioural disturbance in humpback whales.
    1. Cell Biology
    2. Neuroscience

    The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs

    Thibaut Laboute, Jorge Gandía ... Jérôme AJ Becker
    GPR88 inhibits G-protein signaling of nearby GPCRs, and dampens b-arrestin recruitment by all GPCRs tested, likely by sequestration in intracellular compartments.
  1. Webinar Report: Engaging with wider audiences

    What do you need to consider when communicating with different audiences?
  2. Travel Grants: The first winners of 2019

    Five women and two men receive the first round of eLife early-career travel awards this year.
  3. The natural history of a curator: an interview with Ben Price

    Growing up on a game ranch in Zimbabwe stimulated Ben Price’s fascination with insects – “the sheer diversity of insects makes it impossible to not be interested once you start looking”. He continued to explore nature during a PhD on the evolutionary history of cicadas, and two postdocs. Now, he is the senior curator of Odonata and Small Orders, an eclectic group that includes land-based and aquatic insects, at the Natural History Museum in London.
  4. Mental Health in Academia: What about faculty?

    Hilal A Lashuel
    After two heart attacks in three years, an associate professor discusses the challenges of faculty life.
    1. Ecology

    Thermoregulation: Bugs battle stress from hot blood

    Joshua B Benoit, David L Denlinger
    A heat exchange mechanism in the head of kissing bugs helps to prevent stress and regulate their temperature while they feed on warm blood.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane

    Assaf Elazar, Jonathan Weinstein ... Sarel Jacob Fleishman
    Deep sequencing analysis quantifies the hydrophobicity of the plasma membrane and provides restraints for structure modeling of receptor homodimers to atomic precision.