54 results found
  1. Episode 48: June 2018

    In this episode, we hear about why we always have space for dessert, how collecting seeds from large areas could help restoration projects, gut bacteria, the placebo effect and toxoplasmosis.
  2. Episode 37: March 2017

    In this episode we hear about helping people with paralysis to communicate, how exposing mice to nicotine can affect their sons, scaffold-building parasites, the origins of handedness and plain-language summaries of research.
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati et al.
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.
    1. Microbiology and Infectious Disease

    A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

    Aurélia C Balestra et al.
    Multiple steps of the atypical cell cycles underlying Plasmodium gametogony are controlled by a divergent cyclin/cyclin-dependent complex.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles

    Jan Janouškovec et al.
    Apicomplexan-like parasites originated several times independently and many of them contain cryptic plastid organelles, which demonstrate that the parasites evolved from photosynthetic algae.
    1. Cell Biology
    2. Plant Biology

    Abscisic acid dynamics in roots detected with genetically encoded FRET sensors

    Alexander M Jones et al.
    Fluorescent sensors for the hormone abscisic acid have been developed using a high-throughput platform, and used to monitor hormone dynamics in plant roots and leaves.
    1. Microbiology and Infectious Disease

    Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

    Fernando J Sánchez-Valdéz et al.
    Intracellular amastigotes of the Chagas disease agent Trypanosoma cruzi can spontaneously enter an extended state of replicative dormancy, during which time they are resistant to drug treatment both in vitro and in vivo.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

    Jeffrey I Boucher et al.
    The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.
    1. Cell Biology
    2. Immunology and Inflammation

    Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

    Xiao-Dong Li, Zhijian J Chen
    A pattern recognition receptor called toll-like receptor 13 detects pathogens in a manner that is different to that seen in other pathogen sensors.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

    Russell P Swift et al.
    The pyruvate kinase contained in the apicoplast organelle of malaria parasites makes the nucleotide triphosphates required for several processes including transcription of the organellar genome.

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