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    1. Genetics and Genomics
    2. Evolutionary Biology

    Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

    Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology

    Biases of Principal Component Analysis (PCA) in Physical Anthropology Studies Require a Reevaluation of Evolutionary Insights

    Nima Mohseni, Eran Elhaik
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

    Kara Schmidlin, Sam Apodaca ... Kerry Geiler-Samerotte
    Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to environmental change.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Teichoic acids in the periplasm and cell envelope of Streptococcus pneumoniae

    Mai Nguyen, Elda Bauda ... Cecile Morlot
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology

    Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

    Jessica Armand, Sungsoo Kim ... Hee Won Yang
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology

    ALKBH7 mediates necrosis via rewiring of glyoxal metabolism

    Chaitanya A Kulkarni, Sergiy M Nadtochiy ... Paul S Brookes
    Multi-omics reveals that Alkb homolog 7 (ALKBH7), α mitochondrial alpha-ketoglutarate dioxygenase of unclear function, regulates glyoxal metabolism, which may explain its role in necrosis and heart attack.
    1. Neuroscience

    Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers

    Timothy S Balmer, Laurence O Trussell
    Distinct inputs to the cerebellum make contact on specific subtypes of target neurons.
    1. Neuroscience

    How many neurons are sufficient for perception of cortical activity?

    Henry WP Dalgleish, Lloyd E Russell ... Michael Häusser
    Targeted optogenetic activation of small ensembles of neurons is sufficient to trigger a behavioral report while recruiting matched network suppression, suggesting exquisite sensitivity despite network mechanisms that maintain sparseness.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat, Matthew W Bowler ... Christopher Swale
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.
    1. Cell Biology

    Cyclin-dependent kinase control of motile ciliogenesis

    Eszter K Vladar, Miranda B Stratton ... Jeffrey D Axelrod
    Cyclin-dependentkinase 2 (Cdk2), the master regulator of S phase events during the cell cycle, controls the earliest step in the motile ciliogenesis pathway in quiescent multiciliatedairway epithelial cells.
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