Mutagenizing sequences enriched with promoter motifs creates gene expression de novo, and helps to understand promoter logic, regulatory evolution, and the birth of de novo genes.
Aphid and mildew read counts leftover from the sequencing of greenhouse plants correlated with the environment of origin of the plants, and allowed the mapping of pathogen resistance genes.
T-regulatory type 1 cells inherit a broad repertoire of epigenetic marks from T-follicular helper T-cells, offering new insights into the developmental biology of this subset.
Yi-Ting Tsai, Nogayhan Seymen ... Mohammad M Karimi
Despite no observed correlation between retrotransposon (RTE) activity and chronological age, the expression of most RTE classes and families except SINEs correlated with biological age-associated gene signature scores.
ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.
Thibaut Sellinger, Frank Johannes, Aurélien Tellier
The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.
