ZCWPW1 has co-evolved with PRDM9, in particular the PRDM9-SET domain, and although not involved in PRDM9's role in positioning recombination events, it is required for PRDM9's role in pairing chromosomes.
Audrey Le Veve, Mathieu Genete ... Vincent Castric
By modulating the intensity of balancing selection at the S-locus, dominance between self-incompatibility alleles shapes the genetic load linked to each allele, creating inbreeding depression in some S-locus homozygotes.
Marco Todesco, Natalia Bercovich ... Loren H Rieseberg
Variation in patterns of floral UV pigmentation is controlled by a single transcription factor in sunflower and affects both pollinator attraction and responses to environmental stresses.
A proximity labeling approach defines germ granule proteome in Caenorhabditis elegans, and identifies LOTUS domain proteins as key regulators of germ granule assembly.
Bonus, the Drosophila TIF1 factor, functions as a repressor of tissue-specific genes in the germline, emphasizing an important function of SUMOylation in transcriptional regulation.
Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.
Phenotypic diversity and cell state transition (i.e., acquisition of a CD44+/CD24- cell state or exposure to TGF-beta) can spur intra-tumor genetic heterogeneity and contribute to acquired resistance.
Comprehensive mutational characterisation of VIM-2 metallo-beta-lactamase deciphered the residues responsible for key functional behavior, including translocation, stability, substrate recognition and catalysis.
Integrated multi-scale, multi-tool approach to design novel 'evolution drugs' which can delay the emergence of antibiotic resistance by constraining bacterial evolutionary escape strategies.
