Tree crickets can optimize the baffles they make to increase call loudness without any progressive optimization, and manufacture an optimal baffle in a single attempt, by using a simple yet highly accurate heuristic.
IL18R+ Tregs constitute a mature thymus-resident population, resistant to thymus involution and endowed with higher capacity to populate the thymus compared to their IL18R– or IL18R deficient counterparts.
Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.
Metabolic flux analysis, biochemistry assays, and functional confirmation in mice show that the ubiquitination and degradation of ATP-citrate lyase (ACLY) mediated by CUL3-KLHL25 promotes the switch from fatty acid synthesis to fatty acid oxidation for iTreg differentiation.
Parallel horizontal gene transfer has spread a bacteriolytic gene family to all domains of life, and has bestowed a niche-transcending adaptation in recipients that must deploy antibacterial molecules to survive in a bacterial world.
Single-cell RNA-sequencing analyses and functional studies define heterogeneity within the pancreatic ductal tree and unique properties of subpopulations of duct cells including an epithelial-mesenchymal transcriptomic axis and roles in chronic pancreatic inflammation.