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    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans

    Gurmeet Kaur et al.
    Prokaryotic TRADD-N and Death-like adaptor domains in diverse predicted apoptosis and immune systems from multicellular prokaryotes and metazoans indicate the common origin of key apoptosis mechanisms required for the stabilization of multicellularity.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Allosteric conformational ensembles have unlimited capacity for integrating information

    John W Biddle et al.
    The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
    1. Neuroscience

    The organizational principles of de-differentiated topographic maps in somatosensory cortex

    Peng Liu et al.
    SI topographic finger maps of older adults show signs of cortical aging but do not show classical hallmarks of cortical de-differentiation.
    1. Evolutionary Biology

    Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

    Claudia Igler et al.
    The number and effects of mutations leading to full drug resistance crucially determine treatment failure probability and should be used to inform antimicrobial treatment strategies with regard to avoidance of resistance emergence.
    1. Structural Biology and Molecular Biophysics

    Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

    Daniel K Weber et al.
    A spectroscopic analysis of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-phospholamban membrane complex reveals the importance of the relative transmembrane orientation for inhibition or activation of the ATPase.
    1. Epidemiology and Global Health

    Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers

    Christopher J Gill et al.
    Longitudinal qPCR-based pertussis surveillance of a low-resource African cohort reveals frequent asymptomatic pertussis infections in both young infants and mothers and suggests possible early warning signals for epidemic outbreaks.
    1. Cell Biology
    2. Neuroscience

    Short and long sleeping mutants reveal links between sleep and macroautophagy

    Joseph L Bedont et al.
    Unbiased and targeted genetic approaches reveal a link between sleep and autophagy that could be relevant for sleep function, and for understanding pathological consequences of chronic sleep loss.
    1. Developmental Biology

    Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

    Wenqing Li et al.
    Genetic studies reveal that mosaic inactivation of ccm2 causes characteristic cerebral cavernous malformations in adult zebrafish and aberrant responses to blood flow that induce the formation of a lethal embryonic multi-cavernous venous malformation.
    1. Cell Biology
    2. Immunology and Inflammation

    Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

    Nadja Kern et al.
    Manipulating nanoscale spacing of Fcγ receptors using DNA origami demonstrates that ligand clustering regulates receptor phosphorylation and phagocytosis.