74 results found
  1. May 2014

    Episode 12: May 2014

    In this episode we hear about the neuroscience of chewing, skin cancer, African sleeping sickness, an ancient protein complex, and our editor-in-chief shares his thoughts on scientific publishing.
    1. Microbiology and Infectious Disease

    The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

    Stephen Patterson et al.
    Biological and pharmacokinetic studies indicate that the anti-tubercular drug, delamanid, could be repurposed for the treatment of visceral leishmaniasis.
    1. Evolutionary Biology

    The genomes of polyextremophilic cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions

    Alessandro W Rossoni et al.
    Horizontal gene transfer (HGT) analysis in polyextremophile red algae (Cyanidiales) provides explanations for the nonexistence of cumulative effects and eukaryotic pangenomes, and highlights differences between HGT and native genes.
  2. Road

    Innovation Leaders 2020: Introducing the cohort

    We announce the participants and projects joining our new mentorship and open leadership training programme.
    1. Epidemiology and Global Health

    Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults

    Flavia Camponovo et al.
    Malaria pre-exposed volunteers exhibit large breadth of humoral immune responses, with strong variation between individuals, which might compromise vaccine-induced humoral immune response due to natural imprinting.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Length-dependent disassembly maintains four different flagellar lengths in Giardia

    Shane G McInally et al.
    Giardia, a multi-ciliated parasitic protist, maintains four different flagellar lengths by balancing flagellar length-independent IFT-mediated assembly with length-dependent kinesin-13 mediated disassembly.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Basalin is an evolutionarily unconstrained protein revealed via a conserved role in flagellum basal plate function

    Samuel Dean et al.
    Basalins are intrinsically disordered proteins with astonishingly high-sequence divergence that are essential for building the transition zone basal plate and for proper central pair nucleation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Identification of cryptic subunits from an apicomplexan ATP synthase

    Diego Huet et al.
    A phylum-specific ATP synthase subunit is needed for proper mitochondrial function and stability of the complex in Toxoplasma gondii.
    1. Ecology

    Dynamic metabolic exchange governs a marine algal-bacterial interaction

    Einat Segev et al.
    Physical and chemical interactions with bacteria influence the life and death of Emiliania huxleyi, a bloom-forming micro-alga important in global biogeochemical cycles.

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