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    1. Cell Biology
    2. Computational and Systems Biology

    Microtubule reorganization during female meiosis in C. elegans

    Ina Lantzsch, Che-Hang Yu ... Stefanie Redemann
    Structural rearrangements of meiotic spindles during the transition from metaphase to anaphase can be controlled by local changes of microtubule dynamics, such as nucleation and/or turnover, and that katanin promotes microtubule turnover by severing microtubules near the chromosomes.
    1. Biochemistry and Chemical Biology

    High-throughput proteomics of nanogram-scale samples with Zeno SWATH MS

    Ziyue Wang, Michael Mülleder ... Markus Ralser
    Zeno SWATH MS, a novel data-independent acquisition technique in proteomics, which by facilitating sensitive detection in high-throughput experiments with low sample amounts, mitigates current bottlenecks of high-throughput proteomics.
    1. Developmental Biology

    Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

    Ruth M Williams, Martyna Lukoseviciute ... Marianne E Bronner
    A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.
    1. Structural Biology and Molecular Biophysics

    Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

    Tej Kandola, Shriram Venkatesan ... Randal Halfmann
    The disease-associated aggregation of polyglutamine begins in a single molecule with a specific structure.
    1. Neuroscience

    A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

    June K Corrigan, Deepti Ramachandran ... Alexander S Banks
    The metabolic rate of mice is disproportionately affected by the site of experimentation, affecting the phenotypic interpretation of genetically modified strains.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bacterial flagella grow through an injection-diffusion mechanism

    Thibaud T Renault, Anthony O Abraham ... Marc Erhardt
    Single cell, fluorescent microscopy and mathematical modeling reveal how bacterial flagella dynamically assemble outside the cell.
    1. Biochemistry and Chemical Biology

    Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

    Susanne Gerndt, Cheng-Chang Chen ... Christian Grimm
    The lysosomal ion channel TPC2 emerges as an example of an ion channel in which ion selectivity is not fixed but rather agonist-selective.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Expression noise facilitates the evolution of gene regulation

    Luise Wolf, Olin K Silander, Erik van Nimwegen
    In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study

    Amanda M Hughes, Eleanor Sanderson ... Neil M Davies
    It is unclear how much a child's BMI at age 8 affects their depressive and ADHD symptoms after family-level factors are accounted for, but a substantial impact on anxiety symptoms is unlikely.
    1. Neuroscience

    Single neurons and networks in the claustrum integrate input from widespread cortical sources

    Andrew M Shelton, David K Oliver ... Adam M Packer
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