Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.

Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.

Dysfunctionaladipose tissue puts obese and type 2 diabetic patients at higher risk.

A chromatin remodeling factor cooperates with Wnt signaling pathway to transcribe erythropoietin in the adult liver, inducing its secretion and a dramatic erythropoiesis in the spleen.

Malaria pre-exposed volunteers exhibit large breadth of humoral immune responses, with strong variation between individuals, which might compromise vaccine-induced humoral immune response due to natural imprinting.

Dissecting structural, cellular and molecular differences between transplanted and spontaneous mouse tumor models, highlighting their relevance for predicting the efficacy of anti-cancer treatments in patients.

Uncovering a mechanism for how inflammatory signaling is opposed by a phosphatase identifies a potential druggable target to treat E. coli sepsis.

Natural activity of the antimicrobial peptide Defensin includes execution of tumour cell death by tumour necrosis factor in Drosophila.

Activated Drosophila macrophages undergo transient metabolic remodeling towards Hypoxia inducible factor 1 α-driven aerobic glycolysis, a program that induces systemic metabolic changes and is crucial for resistance to infection.