166 results found
    1. Structural Biology and Molecular Biophysics

    Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

    Chunguang Kong et al.
    Structural and functional studies of a potassium ion channel that is opened and closed by different ligands have revealed a novel gating mechanism.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stability-mediated epistasis constrains the evolution of an influenza protein

    Lizhi Ian Gong et al.
    Some of the mutations that occur during influenza evolution can only be tolerated in conjunction with other mutations that increase the stability of a viral protein.
    1. Developmental Biology

    Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

    Ainhoa Pérez-Garijo et al.
    A common mechanism might regulate the communal death of cells in flies and mammals.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes

    Ahmed Rattani et al.
    Shugoshin-like protein 2 (Sgol2) is involved in a variety of cell cycle process during the first stage of meiotic division.
    1. Neuroscience

    A neural mechanism of speed-accuracy tradeoff in macaque area LIP

    Timothy Hanks et al.
    To establish a trade-off between the speed and accuracy of a decision, neurons in lateral intraparietal cortex combine evidence bearing on the decision with a signal that incorporates the cost of time into the decision-making process.
    1. Neuroscience

    Neuronal connectome of a sensory-motor circuit for visual navigation

    Nadine Randel et al.
    Three-dimensional mapping of the neural circuitry that controls movement of a marine worm in response to light provides insights into the evolution of complex visual systems.
    1. Neuroscience

    Reconceiving the hippocampal map as a topological template

    Yuri Dabaghian et al.
    Empirical evidence suggests that the hippocampus constructs maps of spatial environments based on the relative locations of places (i.e., topology), rather than absolute distances and coordinates (i.e., geometry).
    1. Structural Biology and Molecular Biophysics

    Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

    Joseph Atherton et al.
    Cryo-electron microscopy reconstructions of two microtubule-bound transport kinesins at 7 Å resolution reveal how microtubule track binding stimulates ADP release, primes the active site for ATP binding and enables force generation.
    1. Cell Biology
    2. Human Biology and Medicine

    miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

    Taichi Isobe et al.
    Insights into the roles and mechanisms of two of the miRNAs upregulated in human breast cancer stem cells in at least some breast cancers are presented.
    1. Developmental Biology
    2. Immunology and Inflammation

    The extraembryonic serosa is a frontier epithelium providing the insect egg with a full-range innate immune response

    Chris G C Jacobs et al.
    Contrary to the current perception, insect eggs are very capable of defending themselves against pathogens.

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