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Computational and Systems Biology
Spatiotemporal establishment of dense bacterial colonies growing on hard agar
Mya R Warren et al.
A 3D model captures the growth and expansion dynamics of bacterial colonies, revealing distinct effects of surface tension, mechanical forces, and nutrients on the speed of radial and vertical expansion.
Physics of Living Systems
Adaptation of olfactory receptor abundances for efficient coding
Tiberiu Teşileanu et al.
A model of efficient coding by olfactory neurons explains context-dependence observed in the effect of perturbations to the olfactory environment.
Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10
Lalanti Venkatasubramanian et al.
Ig domain family members DIP-alpha and Dpr10 are required in a subset of Drosophila leg motor neurons and muscles, respectively, to establish their fine terminal branching pattern and synapses.
Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification
Rodrigo M Young et al.
Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
Physics of Living Systems
Negative reciprocity, not ordered assembly, underlies the interaction of Sox2 and Oct4 on DNA
John W Biddle et al.
Rigorous reanalysis of single-molecule data yields evidence for energy expenditure in the interaction of transcription factors on DNA.
Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness
Daan B Wesselink et al.
fMRI results show that despite arm amputation, and varying degrees of phantom sensations, canonical hand representation in primary somatosensory cortex is largely maintained.
Differential regulation of the
sleep homeostat by circadian and arousal inputs
Jinfei D Ni et al.
Functional imaging and circuit mapping in the
brain identifies neuropils where sleep-promoting and arousal-promoting neuronal networks converge.
Structural Biology and Molecular Biophysics
The role of scaffold reshaping and disassembly in dynamin driven membrane fission
Martina Pannuzzo et al.
Computational modeling of a dynamin-constricted membrane neck can rank proposed shape changes of the helical scaffold in terms of their fission aptitude and elucidate the associated pathways.
Functionally defined white matter of the macaque monkey brain reveals a dorso-ventral attention network
Ilaria Sani et al.
Primate attention is not limited to a dorsal fronto-parietal network, but includes a ventral temporal node and its dorso-ventral interactions with other attentional areas.
Immunology and Inflammation
Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization
Wenxin Ma et al.
TGFβ signaling to retinal microglia is central to the regulation of neuroinflammatory responses relevant to age-related macular degeneration (AMD), a leading cause of blindness in the developed world.
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