3,096 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bile salt receptor complex activates a pathogenic type III secretion system

    Peng Li et al.
    Microbial genetics and biophysical analyses provide insight into an evolutionarily conserved bile salt receptor complex used by pathogenic bacteria to sense their environment.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    In situ structural analysis of the Yersinia enterocolitica injectisome

    Mikhail Kudryashev et al.
    The basal body of the type-III secretion system of Yersinia enterocolitica within bacterial membranes shows elasticity and is longer than related isolated systems.
    1. Microbiology and Infectious Disease

    A protein secreted by the Salmonella type III secretion system controls needle filament assembly

    Junya Kato et al.
    A novel component of type III protein secretion systems involved in the assembly of the secretion machine is reported.
    1. Microbiology and Infectious Disease

    Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

    Shehryar Ahmad et al.
    A widespread family of chaperones functions to stabilize membrane protein effectors by mimicking transmembrane helical environments and promotes effector export by the bacterial type VI secretion system.
    1. Cell Biology
    2. Physics of Living Systems

    Bridging the gap between single-cell migration and collective dynamics

    Florian Thüroff et al.
    A computational model, based on single-cell features like contractility and polarizability, quantitatively describes cellular dynamics from the single cell level up to small cohorts and confluent tissues.
    1. Cell Biology
    2. Physics of Living Systems

    A physical mechanism of TANGO1-mediated bulky cargo export

    Ishier Raote et al.
    TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
    1. Structural Biology and Molecular Biophysics

    Structure of a type IV pilus machinery in the open and closed state

    Vicki AM Gold et al.
    Electron cryo-tomography reveals a huge conformational change in the secretin domain of the type IV pilus machinery that occurs when the channel opens for pilus extrusion.
    1. Microbiology and Infectious Disease

    Visualization of the type III secretion mediated Salmonella–host cell interface using cryo-electron tomography

    Donghyun Park et al.
    Visualization of the type III secretion mediated Salmonella-host cell interface reveals the intact translocon and the profound remodeling of the host membrane at unprecedented resolution.
    1. Developmental Biology

    Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2

    Xiaobo Wang et al.
    Complementary effects of FBF-1 and FBF-2 on germline stem cell dynamics result from their distinct cooperation with mRNA deadenylase resulting in the opposite effects on the shared target mRNAs.
    1. Cell Biology

    Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

    Albert Lu et al.
    A screen using artificially barcoded, exosomal microRNAs, paired with CRISPR guide RNAs, helped identify new players in multivesicular endosome exocytosis and a role for Wnt signaling.

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