30 results found
    1. Biochemistry and Chemical Biology

    Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

    Andrea Pawellek et al.
    Hinokiflavone is identified as a splicing modulator that blocks progression from spliceosome complex A to complex B and inhibits SUMO protease SENP1, causing hyper-SUMOylation affecting 6 U2 snRNP proteins.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction

    Jean-Baptiste Fourmann et al.
    Prp43 binds to the pre-mRNA and contacts predominantly U2 proteins in the budding yeast spliceosome.
    1. Cancer Biology
    2. Human Biology and Medicine

    Cancer Therapeutics: Partial loss of genes might open therapeutic window

    Bo Liu, Omar Abdel-Wahab
    The loss of genes that encode RNA splicing factors weakens cancer cells in a way that could be exploited by new approaches to treatment.
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    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing

    Carlos Gorbea et al.
    iRICC, a new method to identify RNA-RNA interactions in vivo, provides mechanistic insight into the function of a viral non-coding RNA.
    1. Cell Biology

    Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation

    Claudia Pellacani et al.
    Extensive cytological and biochemical analyses show that the conserved Sf3A2 and Prp31 splicing factors bind microtubules and the Ndc80 complex, playing direct mitotic functions in both Drosophila and human mitosis.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

    Damian Kao et al.
    The first malacostracan genome sequence will establish the genetically tractable Parhyale hawaiensis as a model organism in this key animal group.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

    Sunbin Liu et al.
    Structural and functional analyses show how the spliceosomal Prp3 protein concomitantly binds double- and single- stranded regions in U4/U6 di-snRNAs and serves to stabilize the U4/U6•U5 tri-snRNP for splicing.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

    Matthew T Parker et al.
    Sequencing mRNA directly with nanopores can reveal the authentic combinations of multiple mRNA processing events in full-length mRNA molecules in addition to identifying base modifications.
    1. Chromosomes and Gene Expression

    The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis

    Roland Ivanyi-Nagy et al.
    A messenger RNA coding for the histone 1.2 protein negatively regulates telomere elongation by interacting with human telomerase RNA.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synergistic assembly of human pre-spliceosomes across introns and exons

    Joerg E Braun et al.
    Viewing the dynamic interactions of individual spliceosomal subcomplexes with single pre-messenger RNA molecules reveals how nearby flanking splice sites accelerate pre-spliceosome assembly and the splicing of multi-intron pre-mRNAs.

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