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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synergistic assembly of human pre-spliceosomes across introns and exons

    Joerg E Braun et al.
    Viewing the dynamic interactions of individual spliceosomal subcomplexes with single pre-messenger RNA molecules reveals how nearby flanking splice sites accelerate pre-spliceosome assembly and the splicing of multi-intron pre-mRNAs.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing

    Somsakul Pop Wongpalee et al.
    A protein regulator of alternative pre-mRNA splicing arrests spliceosome assembly at a previously unrecognized step that defines new intermediate stages in the formation of exon complexes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

    André Mourão et al.
    Interactions with Sm proteins can provide a way in which regulatory factors can modulate alternative splice site choices.
    1. Cancer Biology

    Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

    Brenton R Paolella et al.
    Partial copy loss of spliceosome genes are common non-driver gene dependencies in cancer.
    1. Structural Biology and Molecular Biophysics

    Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition

    Yasushi Kondo et al.
    The complete architecture of human spliceosomal U1 snRNP and its interaction with the 5′ splice site of pre-mRNA are described in atomic detail.
    1. Chromosomes and Gene Expression

    Viral-induced alternative splicing of host genes promotes influenza replication

    Matthew G Thompson et al.
    Infection of human cells by influenza A virus induces changes in the alternative splicing of host genes that, in turn, promote viral replication.
    1. Genetics and Genomics

    Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila

    Iryna Shakhmantsir et al.
    Alternative splicing provides a mechanism to maintain oscillations of the circadian clock.
    1. Computational and Systems Biology

    The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture

    Athma A Pai et al.
    Surprising connections between gene architecture and splicing kinetics are illuminated using short, progressive metabolic labeling/RNA sequencing and novel computational modeling approaches in Drosophila cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dynamics and consequences of spliceosome E complex formation

    Joshua Donald Larson, Aaron A Hoskins
    Single molecule fluorescence analysis of spliceosome E complex formation reveals how tuning of U1 binding to the 5' SS facilitates efficient capture of the snRNP by pre-mRNAs.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

    Thomas D Baird et al.
    A whole-genome siRNA screen identifies ICE1 as a factor required for accurate sensing and quality control of mRNAs containing premature stop codons.