SIRT4 regulates cellular communication network factor 2 expression through U2 small nuclear RNA auxiliary factor 2-mediated pre-mRNA splicing, presenting a potential therapeutic target for kidney fibrosis.

RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.

The 3'-end formation complex CFIm regulates S-adenosylmethionine (SAM) homeostasis by promoting the splicing of the SAM synthetase transcript, MAT2A.

A protein regulator of alternative pre-mRNA splicing arrests spliceosome assembly at a previously unrecognized step that defines new intermediate stages in the formation of exon complexes.

KIS, a kinase upregulated in the developmental brain, phosphorylates the PTBP2 splicing complex and modulates alternative exon usage for proper synaptic spine emergence and maturation.

Real-time single-molecule visualization of transcription and splicing in living cells reveals that RNA synthesis and processing can occur through multiple pathways on the same gene.

Inhibiting PRMT1 enzymatic activity promotes megakaryocyte terminal differentiation via RBM15-mediated RNA metabolism, which is dysregulated in hematological malignancies.

The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.

Mouse TRIP13 localizes to synapsed chromosomal axes and thus exhibits mutually exclusive localization with HORMAD1/HORMAD2, providing a cell biological explanation for dissociation of HORMAD1/2 from chromosomal axes upon synapsis.

HNRNPM regulates exon inclusion and circularization events on transcripts of key homeostatic genes promoting cancer growth.