190 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

    Emma Carley et al.
    Forces stemming from cell-matrix adhesions, but not cell-cell adhesions, are directly transmitted to the nuclear lamina to regulate epidermal cell fate.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra

    Jack F Cazet et al.
    Injuries activate the oral identity-specifying canonical Wnt signaling pathway in Hydra, which can trigger head regeneration in permissive tissue contexts created by the absence of pre-existing organizers.
    1. Developmental Biology

    In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration

    Mira I Pronobis et al.
    Proximity labeling-based proteomic strategies applied in zebrafish identify new insights into protein network changes in heart muscle cells during regeneration and implicate Rho A as a target of ErbB2 signaling during zebrafish heart regeneration.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

    Elliott Swanson et al.
    Simultaneous multimodal measurement of chromatin accessibility, gene expression, and protein expression provides a unified view of the molecular underpinnings of immune cell state in health and disease.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

    Jinmi Choi et al.
    Temporal changes in genome-wide enhancer transcription activity during a transdifferentiation event reveal additive and synergistic enhancer cooperation.
    1. Developmental Biology
    2. Neuroscience

    Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants

    J Roman Arguello et al.
    Targeted expression of molecular probes for gene expression and chromatin accessibility in subpopulations of neurons in the Drosophila olfactory system identifies genes required for their development and function.
    1. Genetics and Genomics

    Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

    Helen M Tauc et al.
    Global, multi-angled genetic analyses identified an age-associated loss of stem cell lineage fidelity that was linked to changes in polycomb regulation in the Drosophila intestinal epithelium.
    1. Genetics and Genomics

    Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees

    Briana E Mittleman et al.
    A comparative analysis of human and chimpanzee polyadenylation site usage establishes alternative polyadenylation as another key mechanism underlying the genetic regulation of transcript and protein expression levels in primates.

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