488 results found
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Criterion placement threatens the construct validity of neural measures of consciousness

    Johannes J Fahrenfort, Philippa A Johnson ... Simon van Gaal
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Immunology and Inflammation

    RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

    Alejandro Rosell, Agata A Krygowska ... Esther Castellano
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Solid
    1. Evolutionary Biology
    2. Genetics and Genomics

    Template switching during DNA replication is a prevalent source of adaptive gene amplification

    Julie N Chuong, Nadav Ben Nun ... David Gresham
    Template switching during DNA replication is a frequent source of adaptive gene amplification.
    1. Medicine
    2. Neuroscience

    Cold induces brain region-selective cell activity-dependent lipid metabolism

    Hyeonyoung Min, Yale Y Yang, Yunlei Yang
    It is of significance in identifying temperature sensitive brain regions in brain energy metabolism, as which might provide potential targetable sites in the treatment of brain lipid metabolism-associated neurological disorders.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

    Long-Feng Lu, Can Zhang ... Shun Li
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Medicine

    Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state

    Yao Li, Hui Xin ... Wei Zhang
    Low estrogen levels in postmenopausal hypertension are linked to metabolic reprogramming and aortic tissue changes, with L-alpha-aminobutyric acid emerging as a potential protective biomarker.
    1. Genetics and Genomics

    3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity

    Khanh B Trang, Matthew C Pahl ... Struan FA Grant
    Integration of GWAS summary statistics with extensive 3D genomic datasets generated in a myriad of different cell types provides genomic insights into pediatric obesity pathogenesis.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid

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