For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.

The phosphatase Fcp1 inactivates Greatwall kinase at the end of mitosis.

Palmitoylation recruits the phosphatase SCP1 to endothelial cell membranes where it negatively regulates Akt kinase activity, resulting in suppressed angiogenesis and decreased tumorigenesis.

Urp1 and Urp2 peptides, expressed in CSF-contacting neurons in the spinal canal, prevent abnormal curvature of the zebrafish spine.

Dot1l and its H3K79 methyltransferase activity are required for thermogenesis, and Dot1l is recruited by Zc3h10 to its targets genes to alter chromatin accessibility to activate the thermogenic gene program.

Functional and computational studies reveal that the allosteric inhibition mechanism is conserved between glutamate and neutral amino acid transporters of the SLC1 family, and identify a novel allosteric inhibitor.

Genetic and molecular analyses identify and characterize an evolutionary battle over lysis timing wherein a bacteriophage delays lysis through lysis inhibition while a defensive phage satellite accelerates lysis.

TAF7L acts as a molecular switch that regulates the development of mesenchymal stem cells.

A novel master regulatory mechanism of cell proliferation and senscence employs the lncRNA UCA1 and a CAPERα/TBX3 corepressor.

A series of functional assays in mouse models and primary brown adipocytes confirm that the ACE2 pathway regulates glucose and lipid homeostasis, and maintains thermogenesis and systemic energy metabolism by both the Akt and PKA signaling.