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Biochemistry and Chemical Biology
Cell Biology
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62
Rowena DeJesus et al.
FACS-based pooled CRISPR screening is a powerful forward genetic tool to interrogate cellular pathways and targets that modulate protein fate.
Cell Biology
Plant Biology
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress
Madlen Stephani et al.
C53 bridges selective autophagy with ribosome-associated quality control at the endoplasmic reticulum.
Biochemistry and Chemical Biology
Cell Biology
AMPylation matches BiP activity to client protein load in the endoplasmic reticulum
Steffen Preissler et al.
Attaching a molecule of adenosine mono-phosphate (AMP) to the BiP protein at threonine 518 regulates its chaperone activity in the endoplasmic reticulum.
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