Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.

Long-term increased testosterone improved body composition and bone density, but lowered HDL and raised risks of hypertension, androgenic alopecia, prostate cancer, and spinal stenosis in males.

Many of the effects of intelligence on health and social outcomes later in life are mediated via education.

Imaging of structure and function in the brain from thousands of participants was used along with genetics and biophysical measures to study many different aspects of how the brain ages.

Genetic evidence in humans suggests that statins reduce cancer risk via a cholesterol-independent pathway.

Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.

Genetic predisposition to uterine leiomyomas arises from variation at loci for genetic stability and genitourinary development, and in part explains the frequent occurrence of the condition in women with African origin.

Polygenic selection signals in humans estimated from previously existing GWAS should be viewed with caution due to concerns about residual population stratification.

The prediction accuracies of polygenic scores in humans vary depending on the characteristics of the samples, as well as based on the study design, within a single ancestry group.

A resource to systematically explore the association between overall genetic risk for 162 risk factors and disease with 551 outcomes.