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    1. Genetics and Genomics

    Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

    Paul RHJ Timmers et al.
    Genomic associations with lifespan principally reflect heart disease/smoking/dementia but not other cancers, and distinguish lifespan differences of five years between top/bottom deciles of a score derived from DNA alone.
    1. Cell Biology

    Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study

    Christi T Salisbury-Ruf et al.
    An integrative approach, combining genetic mouse and large-scale human genetics studies, was used to reveal a novel role for the Bcl-2 protein Bid in maintenance of mitochondrial function that alters susceptibility to myocardial infarction.
    1. Genetics and Genomics
    2. Medicine

    PTPRG is an ischemia risk locus essential for HCO3-dependent regulation of endothelial function and tissue perfusion

    Kristoffer B Hansen et al.
    HCO3-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

    Tamara M Sirey et al.
    Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.
    1. Genetics and Genomics

    Germline burden of rare damaging variants negatively affects human healthspan and lifespan

    Anastasia V Shindyapina et al.
    Rare highly damaging mutations that are present in most human genomes decrease lifespan and are associated with an earlier onset of chronic diseases.
    1. Genetics and Genomics

    GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

    Nasa Sinnott-Armstrong et al.
    Across urate, IGF-1, and testosterone, thousands of dispersed variants contribute to heritability, while previously characterized core pathways are highly enriched for associations and reveal feedback mechanisms governing serum biomarker levels.
    1. Genetics and Genomics

    Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes

    Andrew D Skol et al.
    Integrating gene expression with genetic association data provided insights into the functional relevance of genetic risk for a complex disease, thus implicating folliculin as a putative diabetic retinopathy susceptibility gene.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Demographic history mediates the effect of stratification on polygenic scores

    Arslan A Zaidi, Iain Mathieson
    Correction for stratification in genome-wide association studies should be informed by the demographic history of the sample.
    1. Neuroscience

    Empirical examination of the replicability of associations between brain structure and psychological variables

    Shahrzad Kharabian Masouleh et al.
    Empirical evaluations demonstrate the low probability of finding and replicating significant associations between psychological tests and brain structure in healthy adults, highlighting the importance out-of-sample replication of exploratory findings.
    1. Neuroscience

    Imaging: The many facets of brain aging

    Lars Nyberg, Anders Wåhlin
    Applying big-data analytic techniques to brain images from 18,707 individuals is shedding light on the influence of aging on the brain.
    Insight
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