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An extensive program of periodic alternative splicing linked to cell cycle progression
Daniel Dominguez et al.
Extensive periodic regulation of alternative splicing during the cell cycle in genes is linked to cell cycle functions, and involves an auto-inhibitory mechanism that uses the protein kinase CLK1.
Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability
Ana Maria G Dumitru et al.
Quantitative phosphoproteomics defines the substrates for Cyclin A/Cdk1 kinase during early mitosis and follow up studies validate that one identified substrate, MYPT1, influences the stability of k-MT attachments by regulating Plk1.
GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor
Jenna L Jewell et al.
Protein kinase A (PKA) phosphorylates Raptor and inhibits mammalian target of rapamycin complex 1 (mTORC1) activity.
Biochemistry and Chemical Biology
The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation
Yongjie Wei et al.
Nutrient starvation activates autophagy by a novel signaling mechanism that is blocked by one of the major autophagy inhibitors.
Chromosomes and Gene Expression
Viral-induced alternative splicing of host genes promotes influenza replication
Matthew G Thompson et al.
Infection of human cells by influenza A virus induces changes in the alternative splicing of host genes that, in turn, promote viral replication.
Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis
Vikash Verma, Thomas J Maresca
MT plus-end-mediated recruitment of a cortical pool of ECT2 trigger RhoA activation upon contact, which results in localized contractility during cytokinesis.
Stem Cells and Regenerative Medicine
A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration
Zhihao Jia et al.
Inhibition of Polo-like kinase that has been shown to exhibit antitumor effect unexpectedly disrupts muscle stem cell function, leading to developmental and regenerative failures.
locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity
Ya-Ping Yen et al.
LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
The subiculum is a patchwork of discrete subregions
Mark S Cembrowski et al.
Pyramidal cells of the subiculum, a major output cell type of the hippocampus, can be deconstructed into distinct subtypes that exhibit a patchwork-like organization in space.
NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets
Romaric Bouveret et al.
Some NKX2-5 mutations that cause congenital heart disease retain transcriptional activity and can bind to many off-target genes, in part through their interactions with cofactors.
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