13 results found
    1. Cell Biology
    2. Immunology and Inflammation

    UNC93B1 mediates differential trafficking of endosomal TLRs

    Bettina L Lee et al.
    A transmembrane protein uses distinct mechanisms to regulate the movement of specific toll-like receptors-key immune system components involved in detecting pathogens-to their final locations inside cells.
    1. Cell Biology

    Toll-like Receptors: Different routes to the same destination

    Kachiko Hayashi, Akiko Iwasaki
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    1. Immunology and Inflammation

    IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

    Mark Noviski et al.
    Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
    1. Neuroscience

    Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

    Kwun Nok M Man et al.
    Munc13 proteins are key determinants of large dense-core vesicle (LDCV)-dependent catecholamine release in chromaffin cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

    Xiao-Dong Li, Zhijian J Chen
    A pattern recognition receptor called toll-like receptor 13 detects pathogens in a manner that is different to that seen in other pathogen sensors.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

    Ulrike Künzel et al.
    The protein FRMD8 binds to iRhom and thereby stabilises the iRhom/ADAM17 complex, which is the primary trigger of inflammatory signalling.
    1. Immunology and Inflammation

    B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

    Lieselotte SM Kreuk et al.
    Microbial-sensing TLRs drive responses to the microbiota, while nucleic-acid sensing TLRs control responses to endogenous ligands, revealing novel regulation of B-1a responses through integrated BCR/TLR mediated activation.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Membrane bridging by Munc13-1 is crucial for neurotransmitter release

    Bradley Quade et al.
    Cryo-electron tomography, reconstitution, and electrophysiological data show that a fundamental function of Munc13-1 is to bridge synaptic vesicles to the presynaptic plasma membrane.
    1. Immunology and Inflammation

    TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections

    Hannah P Savage et al.
    B-1 cell unresponsiveness to antigen-stimulation is overcome during infections when Toll-like receptor engagement removes negative regulators of B cell receptor signaling, thereby supporting B-1 cell differentiation to IgM-secreting plasmablasts.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A conserved function for pericentromeric satellite DNA

    Madhav Jagannathan et al.
    Satellite DNA mediates clustering of multiple chromosomes via formation of chromocenter to encapsulate the full complement of the genome into a single nucleus.

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