280 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding et al.
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A long-term epigenetic memory switch controls bacterial virulence bimodality

    Irine Ronin et al.
    Hysteretic switching between virulence states has been observed in a human pathogen.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

    Ryan M McCormack et al.
    Yersinia pseudotuberculosis and enteropathogenic Escherichia coli promote pathogenicity by deamidating the ubiquitin-like protein NEDD8 to block ubiquitin-dependent trafficking of Perforin-2, which is an effector of innate immunity.
    1. Developmental Biology and Stem Cells
    2. Human Biology and Medicine

    Erythropoietin signaling regulates heme biosynthesis

    Jacky Chung et al.
    EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.
    1. Ecology

    Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae

    Tal Luzzatto-Knaan et al.
    Mass spectrometry has potential as a tool for ecological studies and bioprospecting of natural products from marine cyanobacteria and algae.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

    Mitsuhiro Endoh et al.
    PCGF6 links sequence specific target recognition by the MAX/MGA transcription factor complex to PRC1 (polycomb repressive complex 1) -dependent transcriptional silencing of germ cell-specific genes in mouse pluripotent stem cells.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

    Hyun Bong Park et al.
    A new type of hybrid nonribosomal peptide synthetase (NRPS)-like-pteridine synthase biosynthetic pathway has been illuminated via genome mining.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    A mutant with bilateral whisker to barrel inputs unveils somatosensory mapping rules in the cerebral cortex

    Nicolas Renier et al.
    The somatosensory cortex doesn't integrate mixed bilateral inputs, as partially uncrossing projections from the whiskers duplicates their representation by segregating lateralized inputs from each side of the head.
    1. Cell Biology

    Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

    Adam J Reid et al.
    Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.
    1. Cancer Biology

    Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

    Simeon U Springer et al.
    The creation of a non-invasive assay for detecting urothelial cancer could have a profound impact on how we find and treat the disease.

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