The Aire-dependent genes show a preference for short 3’UTR transcript isoforms resulting in the escape from the post-transcriptional repression mediated by miRNAs in medullary thymic epithelial cells.

The crystal structure of Pur-alpha in complex with DNA reveals its molecular mechanisms of nucleic-acid binding and unwinding, allowing for a better understanding of its essential role in neurons.

Neural activity in the visual system is increased in different layers of the neocortex for bottom-up and top-down modulations.

Interactions between HIV-1 Env and human mannose receptor enhance HIV entry but restrict viral egress and spread in the absence of Vpr.

Perceptual learning is specific because of the absence of bottom-up stimulation and top-down modulation at the untrained conditions.

Heterochromatin formation at transposon loci depends on dimerisation of the effector complex that elicits co-transcriptional silencing and this requirement is fulfilled by co-option of the conserved dimerisation hub protein, Cut-up/LC8.

Analyses of fru P1 neurons that express dpr/DIP genes reveal roles for subsets of neurons in courtship, and the roles of Dpr/DIPs and the sex hierarchy in neuroanatomical sexual dimorphism.

HIV-1 Vpr antagonises innate immune sensing of viral and non-viral stimuli by preventing activated IRF3 and NF-κB nuclear transport.

Population cortical recordings and computational network modeling support a novel mechanism underlying spontaneous UP-DOWN dynamics consisting on non-rhythmic transitions between a silent attractor and a low-rate inhibition-stabilized attractor.

RNA virus replication is attenuated by an intrinsic restriction mechanism after introducing CpG/UpA dinucleotides into both non-translated and coding regions of viral genomes, which may be exploited in the design of attenuated virus vaccines.