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    1. Computational and Systems Biology

    Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points

    Uri Barenholz, Dan Davidi ... Ron Milo
    The stability of metabolic autocatalytic cycles that are widespread in central metabolism limits the affinities of enzymes at flux branch points and explains excess expression of these enzymes.
    1. Neuroscience

    Using the past to estimate sensory uncertainty

    Ulrik Beierholm, Tim Rohe ... Uta Noppeney
    For perceptual inference, human observers do not estimate sensory uncertainty instantaneously from the current sensory signals alone, but by combining past and current sensory inputs consistent with a Bayesian learner.
    1. Ecology
    2. Plant Biology
    Arabidopsis illustration

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
    1. Neuroscience

    Neural representations of naturalistic events are updated as our understanding of the past changes

    Asieh Zadbood, Samuel Nastase ... Uri Hasson
    Changes in the interpretation of specific scenes in a narrative trigger corresponding updates in the neural patterns evoked by those scenes in the default mode network.
    1. Neuroscience

    Widespread correlation patterns of fMRI signal across visual cortex reflect eccentricity organization

    Michael J Arcaro, Christopher J Honey ... Uri Hasson
    Functional coupling between visual areas reflects supra-areal eccentricity organization distinct from overlapping receptive field connectivity during both rest conditions and naturalistic movie viewing.
    1. Neuroscience

    A neural network model of when to retrieve and encode episodic memories

    Qihong Lu, Uri Hasson, Kenneth A Norman
    A neural network showed better prediction of upcoming states when it was selective in when it encoded and retrieved episodic memories, thereby explaining why humans show this selectivity in studies of naturalistic memory.
    1. Stem Cells and Regenerative Medicine

    Distinct mechanisms underlie oral vs aboral regeneration in the cnidarian Hydractinia echinata

    Brian Bradshaw, Kerry Thompson, Uri Frank
    Stem cell migration underlies head regeneration in the cnidarian (jellies and their kin) Hydractinia, but the regeneration of other body parts is based on the gradual transformation of one tissue type into another.
    1. Neuroscience

    5'-UTR SNP of FGF13 causes translational defect and intellectual disability

    Xingyu Pan, Jingrong Zhao ... Xu Zhang
    A 5'-UTR SNP of FGF13 impairs PTBP2 interacting with FGF13 mRNA, leading to reduced FGF13 translation and deficits in brain development and cognitive functions.
    1. Evolutionary Biology

    Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity

    Jin Xu, Xinxin Peng ... Chung-I Wu
    Human cell lines regress to become ‘de-sexualized’ by reconfiguring to a 2:3 X/A ratio of high fitness, thus shedding light on the evolution of mammalian sex chromosomes.
    1. Neuroscience

    Cortical plasticity is associated with blood–brain barrier modulation

    Evyatar Swissa, Uri Monsonego ... Alon Friedman
    Neuronal activity modulates blood–brain barrier permeability, influencing synaptic plasticity and local network reorganization in the healthy brain.