22 results found
    1. Cell Biology
    2. Human Biology and Medicine

    Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

    Daniel J Fazakerley et al.
    Lower mitochondrial coenzyme Q was a consistent feature across multiple in vitro and in vivo models of insulin resistance and was sufficient to cause insulin resistance through increased mitochondrial oxidants.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

    Jose U Scher et al.
    The sequencing of microbial genomes reveals that the presence of a particular microbial species in the gut may increase the risk of the autoimmune disease rheumatoid arthritis.
    1. Cell Biology

    HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

    David Wu et al.
    Hemodynamic forces regulate endothelial cell metabolism, which in turn regulates endothelial inflammation.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Overall energy conversion efficiency of a photosynthetic vesicle

    Melih Sener et al.
    The overall energy conversion efficiency is calculated for a bacterial vesicle that harvests solar energy for ATP production on the basis of an atomic-detail structural model.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

    Ombretta Foresti et al.
    Parallel branches of the ERAD pathway regulate sterol synthesis at multiple steps via feedback inhibition.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults

    William E Barry, Carl S Thummel
    Drosophila HNF4 directs a developmental switch at the onset of adulthood that suppresses diabetes by promoting mitochondrial function and supporting glucose-stimulated insulin secretion.
    1. Genetics and Genomics

    The genome of an intranuclear parasite, Paramicrosporidium saccamoebae, reveals alternative adaptations to obligate intracellular parasitism

    C Alisha Quandt et al.
    Parasitic lineages of Rozellomycota are shaped by repeated and independent gene losses.
    1. Cancer Biology

    Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

    Lan-Feng Dong et al.
    A genetic approach documents that mitochondrial DNA moves from donor cells to recipient mtDNA-depleted cells in whole mitochondria and that this restores mitochondrial respiration and the capacity of the cells to form tumours.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Large-scale determination of previously unsolved protein structures using evolutionary information

    Sergey Ovchinnikov et al.
    A new method of protein structure prediction that incorporates residue–residue co-evolution information into the Rosetta structure prediction program was used to develop models for 58 large protein families that had no previous structural information.
    1. Cell Biology
    2. Evolutionary Biology

    Chimeric origins of ochrophytes and haptophytes revealed through an ancient plastid proteome

    Richard G Dorrell et al.
    An in silico reconstruction of a chloroplast that existed hundreds of millions of years ago casts new insights in the evolutionary processes, endosymbioses and chimerism events that shape the origin of plastids.

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