14 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

    Melesse Nune et al.
    The histone chaperone FACT and the deubiquitinating enzyme Ubp10 act in concert to remove ubiquitin from histone H2B in nucleosomes, and likely coordinate nucleosome assembly during DNA replication and transcription.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion

    Tânia Simões et al.
    A signaling pathway—comprising a linear sequence of the ubiquitin-selective chaperone Cdc48/p97 and the deubiquitylases Ubp12 and Ubp2—synergistically regulates mitochondrial fusion, thereby fine-tuning ubiquitylation of the mitofusin Fzo1.
    1. Biochemistry and Chemical Biology

    SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

    Kate E Coleman et al.
    Aberrant neddylation of non-cullin substrates disrupts normal cell cycle progression.
    1. Cell Biology

    Ubiquitin turnover and endocytic trafficking in yeast are regulated by Ser57 phosphorylation of ubiquitin

    Sora Lee et al.
    Ser57 phosphorylation regulates ubiquitin homeostasis by inhibiting deubiquitylase-mediated recycling and promoting vacuolar degradation.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

    Ramasubramanian Sundaramoorthy et al.
    The unwrapping two turns of DNA on Chd1-bound nucleosomes cause the histone H3 tail and ubiquitin to be re-positioned.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of the 90S small subunit pre-ribosome

    Qi Sun et al.
    The nearly complete architecture of the gigantic 90S precursor of small ribosomal subunit is determined by cryo-EM.
    1. Chromosomes and Gene Expression

    Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus

    Philippe Materne et al.
    Building on previous work (Materne et al., 2015), it is shown that the ubiquitylation of histone H2B represses cell differentiation by opposing chromatin remodeling at the promoter of the master regulator of gametogenesis, ste11
    1. Plant Biology

    Regulation of rice root development by a retrotransposon acting as a microRNA sponge

    Jungnam Cho, Jerzy Paszkowski
    Retrotransposon-derived messenger RNA plays a critical role in rice root development via sequestration of miR171, which suggests a novel trans-acting regulation by transposable elements.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    UBE2G1 governs the destruction of cereblon neomorphic substrates

    Gang Lu et al.
    Cereblon-based small-molecule degraders rely on the sequential action of ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 to assemble K48-linked polyubiquitin chains on cereblon neomorphic substrates, resulting in their proteasomal degradation.
    1. Cell Biology
    2. Human Biology and Medicine

    Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

    Tom Cornelissen et al.
    Mitophagy occurs in Drosophila flight muscle and dopaminergic neurons in vivo and increases with aging in a PINK1/parkin-dependent fashion.

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