85 results found
    1. Biochemistry
    2. Cell Biology

    Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion

    Tânia Simões et al.
    A signaling pathway—comprising a linear sequence of the ubiquitin-selective chaperone Cdc48/p97 and the deubiquitylases Ubp12 and Ubp2—synergistically regulates mitochondrial fusion, thereby fine-tuning ubiquitylation of the mitofusin Fzo1.
    1. Cell Biology
    2. Neuroscience

    Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa

    Fushun Fan et al.
    Analyses of knockout mice and a biochemical screen of interacting proteins reveal that exophilin-8 forms a large network of protein interactions to efficiently retain secretory granules beneath the plasma membrane for exocytosis.
    1. Immunology

    The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB

    Dominik Schmiedel et al.
    The well-established oncogene IMP3 impairs the interaction between cancer cells and the immune system.
    1. Genes and Chromosomes

    RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit

    Laura Milligan et al.
    Ubiquitination close to the active site of RNAPII occurs in response to RNA processing events and is linked to transcriptional pausing, which is released following Bre5-Ubp3 mediated deubiquitination associated with the nascent transcript.
    1. Cell Biology
    2. Genes and Chromosomes

    Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast

    Noah Dephoure et al.
    Aneuploidy produces a protein expression signature characteristic of altered metabolism and redox homeostasis, and the loss of UBP6 ameliorates several aneuploidy-associated phenotypes.
    1. Cell Biology
    2. Genes and Chromosomes

    TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells

    Barbora Malecova et al.
    Genetic and biochemical evidence shows that the basal transcription machinery of muscle cells invariably relies on TBP/TFIID because TBP2 is not expressed in muscle cells, and thus resolves a longstanding issue raised by previous conflicting data.
    1. Biophysics and Structural Biology
    2. Neuroscience

    A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

    Matthias Lübbert et al.
    A novel region in the CaV2.1 α1 subunit regulates coupling of synaptic vesicles to CaV2.1 calcium channels, synaptic vesicle release and docking, and the size of the fast and total releasable pools of synaptic vesicles.
    1. Developmental Biology and Stem Cells

    DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids

    Sebastian Canovas et al.
    Reproductive fluids help the correct establishment of some epigenetic marks and gene expression in preimplantation pig embryos.
    1. Cell Biology

    Ubiquitin turnover and endocytic trafficking in yeast are regulated by Ser57 phosphorylation of ubiquitin

    Sora Lee et al.
    Ser57 phosphorylation regulates ubiquitin homeostasis by inhibiting deubiquitylase-mediated recycling and promoting vacuolar degradation.

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