33 results found
    1. Cell Biology
    2. Developmental Biology

    Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

    Barak Blum et al.
    Loss of mature β cell identity in diabetes can be prevented and rescued by small molecule inhibitors of the TGFβ pathway.
    1. Microbiology and Infectious Disease

    A serine sensor for multicellularity in a bacterium

    Arvind R Subramaniam et al.
    Biofilm formation by Bacillus subtilis relies on a sensing mechanism for the amino acid serine that does not depend on a dedicated protein or RNA.
    1. Cell Biology
    2. Developmental Biology

    Notochord vacuoles absorb compressive bone growth during zebrafish spine formation

    Jennifer Bagwell et al.
    Live imaging and genetic analyses revealed that notochord vacuoles play a critical role in spine morphogenesis by absorbing vertebral bone growth, thus implicating notochord mechanics in congenital scoliosis.
    1. Developmental Biology

    Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature

    Alexis M Ceasrine et al.
    β2-adrenergic receptors control glucose metabolism by regulating cross-talk between pancreatic islet endocrine cells and vasculature during development.
    1. Microbiology and Infectious Disease

    The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching

    Brittany L Carroll et al.
    In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

    Lian He et al.
    A near-infrared light-stimulable optogenetic platform enables remote and wireless manipulation of calcium signaling and immune responses both in vitro and in vivo to achieve tailored function.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe

    Marisa A Yonemitsu et al.
    A transmissible cancer that arose in a marine mussel spread from a single animal to become a global pathogen affecting two other mussel species in both Europe and South America.
    1. Evolutionary Biology

    The rise and fall of the ancient northern pike master sex-determining gene

    Qiaowei Pan et al.
    Tracing the evolution of an old master sex determination gene reveals a diversity of sex determination transitions, including a complete Y chromosome loss, among an old teleost order (Esociformes).
    1. Cell Biology

    Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

    Huiliang Zhang et al.
    The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development

    Jia Zhao et al.
    In vivo imaging reveals that gradually increased amount of glucose mediates the heterogeneous functional development of individual β-cells by activating its major downstream calcineurin/NFAT signaling pathway.

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