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    1. Genetics and Genomics

    Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo

    Manon Baëza, Séverine Viala ... Samir Merabet
    Short peptide motifs can confer specificity to developmental networks by inhibiting protein–protein interactions.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution

    Josep Martí-Solans, Aina Børve ... Timothy Lynagh
    Expression patterns and biophysical properties of acid-sensing ion channels in numerous bilaterian animals offer insight into the deployment of ion channels by the evolving nervous system in complex animals.
    1. Developmental Biology
    2. Evolutionary Biology

    Gene expression mapping of the neuroectoderm across phyla – conservation and divergence of early brain anlagen between insects and vertebrates

    Nico Posnien, Vera S Hunnekuhl, Gregor Bucher
    Hypotheses on brain homologies between insects and vertebrates are tested by comparing gene expression patterns from flies and beetles with those from vertebrates at early neuroectoderm stages.
    1. Developmental Biology
    2. Evolutionary Biology

    Par protein localization during the early development of Mnemiopsis leidyi suggests different modes of epithelial organization in the metazoa

    Miguel Salinas-Saavedra, Mark Q Martindale
    Even though the ctenophore Mnemiopsis leidyi develops polarized epithelial tissues, polarization is not mediated by the conserved mechanisms polarizing bilaterian and cnidarian epithelial cells.
    1. Evolutionary Biology
    2. Neuroscience

    Large-scale deorphanization of Nematostella vectensis neuropeptide G protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems

    Daniel Thiel, Luis Alfonso Yañez Guerra ... Gáspár Jékely
    The identification of 31 neuropeptide GPCRs in the sea anemone Nematostella vectensis provides a rich resource to study peptidergic signaling in cnidarians and suggests that cnidarian and bilaterian peptidergic systems diversified independent from each other from a few ancestral systems.
    1. Evolutionary Biology

    Early evolution of the ecdysozoan body plan

    Deng Wang, Yaqin Qiang ... Jian Han
    Discovery of new taxon of Saccorhytida suggests that the ground pattern of Ecdysozoa may not be elongated vermiform instead sac-like in shape.
    1. Evolutionary Biology

    Circadian Rhythms: Cnidarians are CLOCKing in

    Erica R Kwiatkowski, Patrick Emery
    Studies of the starlet sea anemone provide important insights into the early evolution of the circadian clock in animals.
    Version of Record
    Insight
    1. Evolutionary Biology

    Functional characterization of a ‘plant-like’ HYL1 homolog in the cnidarian Nematostella vectensis indicates a conserved involvement in microRNA biogenesis

    Abhinandan M Tripathi, Yael Admoni ... Yehu Moran
    Presence of a functional homolog of HYL1 in Nematostella vectensis, a basal animal model, indicates divergent evolution of miRNA biogenesis pathway in plants and animals from an ancestral miRNA system.
    1. Cell Biology
    2. Ecology

    Ubiquitous macropinocytosis in anthozoans

    Philippe Ganot, Eric Tambutté ... Sylvie Tambutté
    Macropinocytosis, the process of non-specific endocytosis, is a major gateway for large volumes of surrounding medium and nanoparticles to coral cells.
    1. Cell Biology

    Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation

    Duccio Conti, Parveen Gul ... Viji M Draviam
    Human chromosome-microtubule attachments are stabilised by Astrin-mediated dynamic delivery of PP1 phosphatase to the attachment site, which ensures the normal segregation of chromosomes.