379 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity

    Michael P Meers et al.
    Post-translational modification of histone H3K36 is not required to suppress cryptic transcription initiation or to include alternative exons in Drosophila; instead it promotes expression of active genes by stimulating polyadenylation.
    1. Evolutionary Biology
    2. Neuroscience

    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

    David Ramos-Vicente et al.
    The animal phylogeny of glutamate receptors indicates that vertebrate types do not account for all receptor classes originated during evolution, neither are they the pinnacle of a linear evolutive process.
    1. Developmental Biology
    2. Evolutionary Biology

    Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

    Aaron L Fidler et al.
    Collagen IV is a primordial extracellular matrix component associated with the transition to animal multicellularity, and enabled the formation and evolution of epithelial tissues.
    1. Cell Biology
    2. Developmental Biology

    Visualizing the metazoan proliferation-quiescence decision in vivo

    Rebecca C Adikes et al.
    During organismal development, CDK activity at mitotic exit is predictive of future cell behavior, indicating whether a cell will divide again or enter a quiescent state.
    1. Evolutionary Biology

    Gene family innovation, conservation and loss on the animal stem lineage

    Daniel J Richter et al.
    The genomes of animal progenitors evolved as mosaics of old, new, rearranged, and repurposed protein domains, genes and pathways and paved the way for the origin and evolution of animals.
    1. Developmental Biology
    2. Evolutionary Biology

    Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity

    Federico Gaiti et al.
    The complex chromatin-based genomic regulatory system controlling developmental gene expression in complex bilaterians predates the evolution of morphological complexity and may have been a prerequisite for the evolution of the first simple multicellular animals.
    1. Cell Biology

    Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades

    Lars Hering et al.
    A newly discovered cytoplasmic intermediate filament in water bears may help these animals to resist extreme environmental conditions.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness

    Adam D Norris et al.
    Synthetic genetic analysis in C. elegans identifies pairs of RNA binding protein genes that play a critical role in organism health and development.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of directional genetic interactions in a metazoan cell

    Bernd Fischer et al.
    A systematic analysis of gene–gene dependencies using high-throughput imaging of cells detects causal and temporal relationships between genes.
    1. Cancer Biology
    2. Computational and Systems Biology

    Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer

    Anna S Trigos et al.
    Cancer is a consequence of the release of basal cellular functions inherited from our unicellular ancestors from the control of regulatory networks that evolved during the emergence of multicellularity.

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