628 results found
    1. Immunology and Inflammation

    Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

    Daisy X Ji et al.
    Repression of type I interferons by SP140 is essential for resistance to Legionella pneumophila and Mycobacterium tuberculosis.
    1. Computational and Systems Biology
    2. Neuroscience

    Flexible theta sequence compression mediated via phase precessing interneurons

    Angus Chadwick et al.
    A new model for phase precession accounts for theta sequence generation, suggests critical roles for interneurons, and predicts circuit properties to optimise memory storage.
    1. Neuroscience

    A genetically defined asymmetry underlies the inhibitory control of flexor–extensor locomotor movements

    Olivier Britz et al.
    Two classes of premotor inhibitory neurons have specific roles in controlling flexor-extensor behaviors in mice, which is the underlying neural mechanism for limb driven movements in terrestrial vertebrates.
    1. Neuroscience

    Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons

    Giulia Faini et al.
    Accumulation of perineuronal nets around parvalbumin (PV)-positive inhibitory interneurons closes visual cortical plasticity by selectively down-regulating thalamic synapses onto PV cells in a sensory-dependent manner.
    1. Neuroscience

    Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

    Ming Chen et al.
    Experiments examining the actions of morphine on single neurons from one of the brain's reward centers, the VTA, reveal the mechanism by which the drug exerts its hedonic effects.
    1. Neuroscience

    Feeding state functionally reconfigures a sensory circuit to drive thermosensory behavioral plasticity

    Asuka Takeishi et al.
    Starvation modulates thermotaxis behaviors in C. elegans via functional reconfiguration of a sensory network by gut-brain signaling.
    1. Neuroscience

    Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area

    Elina Nagaeva et al.
    The midbrain area for salience, reward and aversion in mouse brain harbours among the dopamine cells three subtypes somatostatin-expressing neurons that show combinatorial neurotransmitter phenotypes and interneuron properties.
    1. Neuroscience

    Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion

    Steven Knafo et al.
    Bioluminescence monitoring and selective silencing in zebrafish larva reveal a novel sensorimotor circuit modulating speed in the moving spinal cord.
    1. Neuroscience

    The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord

    Yunuen Moreno-Lopez et al.
    While the corticospinal tract is often considered exclusively as a motor path, a combination of intersectional viral strategy and in vivo electrophysiology reveals that, in the mouse lumbar cord, its main role is the modulation of sensory inputs.
    1. Neuroscience

    Localized inhibition in the Drosophila mushroom body

    Hoger Amin et al.
    A large interneuron in the Drosophila mushroom body has compartmentalized activity, which causes localized inhibition and predicts that Kenyon cells inhibit themselves more than they inhibit other individual Kenyon cells.

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