10,958 results found
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    AP-2α and AP-2β cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development

    Eric Van Otterloo, Isaac Milanda ... Trevor Williams
    In addition to a neural crest cell specific role, AP-2α and AP-2ß cooperatively promote craniofacial development through regulating chromatin and gene expression dynamics in the facial surface ectoderm.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia

    Alex R Schuurman, Tom DY Reijnders ... Tom van der Poll
    Different etiologies of community-acquired pneumonia evoke both shared and diverging immunological responses.
    1. Neuroscience

    Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans

    Oleg Tolstenkov, Petrus Van der Auwera ... Alexander Gottschalk
    The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.
    1. Neuroscience

    Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness

    Michael Troup, Melvyn HW Yap ... Bruno van Swinderen
    Optogenetic activation reveals a larger role for the fly brain 'sleep switch' neurons in controlling both waking and sleeping behavioral responsiveness, partly via a parallel channel involving innexin6 electrical synapses.
    1. Neuroscience

    Brain structure and function link to variation in biobehavioral dimensions across the psychopathological continuum

    Jasper van Oort, Alberto Llera ... Philip FP van Eijndhoven
    The multimodal linked independent component analysis promotes a more integrative understanding of transdiagnostic mechanisms of psychopathology.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Bacterial actin MreB forms antiparallel double filaments

    Fusinita van den Ent, Thierry Izoré ... Jan Löwe
    The prokaryotic actin homologue MreB forms antiparallel double filaments in vitro and in vivo, an architecture that is unprecedented among the actin family of proteins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of the SAS-6 cartwheel hub from Leishmania major

    Mark van Breugel, Rainer Wilcken ... Christopher M Johnson
    The X-ray structure of the SAS-6 cartwheel hub from Leishmania major demonstrates that SAS-6 can be sufficient to determine centriolar cartwheel symmetry.
    1. Cancer Biology

    Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase

    J Edward van Veen, Michael Scherzer ... Martin McMahon
    Two of the most commonly mutated growth factor pathways induce a deadly feature of lung adenocarcinoma.
    1. Neuroscience

    A resource-rational theory of set size effects in human visual working memory

    Ronald van den Berg, Wei Ji Ma
    Set size effects in visual working memory are explained as a resource-rational trade-off between an error-based behavioral cost and a neural encoding cost.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin

    Katharina van Pee, Alexander Neuhaus ... Özkan Yildiz
    The near-atomic cryoEM pore complex structure of pneumolysin, the main virulence factor of Streptococcus pneumoniae, shows how the individual domains rearrange during the pore formation.

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