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    1. Neuroscience

    Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia

    Valeria Oliva, Ron Hartley-Davies ... Jonathan CW Brooks
    Attention-grabbing tasks produce rapid opioid-mediated analgesia via the descending pain modulation network to alter spinal neuronal activity.
    1. Neuroscience

    Modelling the neural code in large populations of correlated neurons

    Sacha Sokoloski, Amir Aschner, Ruben Coen-Cagli
    The proposed techniques enable researchers to disentangle the statistical features of neural population responses, and rigorously quantify how these features carry information about stimuli and experimental variables.
    1. Computational and Systems Biology
    2. Neuroscience

    A functional model of adult dentate gyrus neurogenesis

    Olivia Gozel, Wulfram Gerstner
    The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
    1. Neuroscience

    Detecting Regime Shifts: Neurocomputational Substrates for Over- and Underreactions to Change

    Mu-Chen Wang, George Wu, Shih-Wei Wu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

    Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells

    Madeleine L Hart, Evan Quon ... Lucas B Sullivan
    SDH-null cancer cells decrease mitochondrial complex I to drive rewired aspartate synthesis through reductive carboxylation and pyruvate carboxylase, supporting cell proliferation and tumor growth.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

    Lenno Krenning, Stijn Sonneveld, Marvin E Tanenbaum
    mRNA decay contributes to reshape the transcriptome as a parent cell divides into daughter cells.
    1. Evolutionary Biology
    2. Epidemiology and Global Health
    3. Microbiology and Infectious Disease
    4. Genetics and Genomics

    Evolutionary Medicine: A Special Issue

    Edited by Dominique Soldati-Favre et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the growing and increasingly interdisciplinary field of evolutionary medicine.
    1. Developmental Biology

    Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

    Igor Kondrychyn, Liqun He ... Li-Kun Phng
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Physics of Living Systems

    Negative reciprocity, not ordered assembly, underlies the interaction of Sox2 and Oct4 on DNA

    John W Biddle, Maximilian Nguyen, Jeremy Gunawardena
    Rigorous reanalysis of single-molecule data yields evidence for energy expenditure in the interaction of transcription factors on DNA.