3,548 results found
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of human polycomb repressive complex 2

    Claudio Ciferri, Gabriel C Lander ... Eva Nogales
    Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.
    1. Neuroscience

    Foggy perception slows us down

    Paolo Pretto, Jean-Pierre Bresciani ... Heinrich H Bülthoff
    Virtual reality experiments show that motorists slow down when driving in fog, but they speed up when visibility is reduced equally at all distances.
    1. Biochemistry and Chemical Biology

    Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics

    Syed M Moin, Sinisa Urban
    Intramembrane proteases identify target proteins in a different way from other proteases.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

    Huan Yan, Guocai Zhong ... Wenhui Li
    Biochemical and genetic tests have revealed that a liver protein called NTCP is a functional receptor for hepatitis B and D viruses, which should lead to an improved understanding of the infections caused by these viruses and assist the development of new intervention strategies.
    1. Biochemistry and Chemical Biology

    RecA filament sliding on DNA facilitates homology search

    Kaushik Ragunathan, Cheng Liu, Taekjip Ha
    A DNA–protein complex can find target sequences of bases in another DNA molecule by sliding along it.
    1. Structural Biology and Molecular Biophysics

    Modelling dynamics in protein crystal structures by ensemble refinement

    B Tom Burnley, Pavel V Afonine ... Piet Gros
    A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.
    1. Microbiology and Infectious Disease

    Strong inter-population cooperation leads to partner intermixing in microbial communities

    Babak Momeni, Kristen A Brileya ... Wenying Shou
    Simulations and experiments on systems containing two different populations of microorganisms show that interactions that benefit at least one of the populations can lead to communities with stable compositions, and that strong cooperation between two populations can lead to communities in which both populations are mixed together.
    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak, David S Greenberg ... Jason ND Kerr
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

    Rati Verma, Robert S Oania ... Raymond J Deshaies
    The enzyme that collaborates with ubiquitin ligases to promote the release of defective polypeptides from stalled ribosomes in a process named ribosome-associated degradations has been identified as the ATPase Cdc48.
    1. Neuroscience

    Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans

    Bo-mi Song, Serge Faumont ... Leon Avery
    The nematode worm C. elegans consumes familiar bacterial species more rapidly than it does novel ones, and this preference for familiarity is mediated by a pair of serotonergic neurons.

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