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    1. Cancer Biology

    Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

    Andrea Strakova et al.
    Genetics of a canine transmissible tumour show how the world’s oldest cancer “metastasised” through the global dog population – and captured, maintained and rearranged its mitochondrial DNA along the way.
    1. Neuroscience

    Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

    Margarita C Dinamarca et al.
    A protein called RNF10 relays messages from synapses to neuron cell nuclei, and is responsible for long-lasting modifications of dendritic spines as observed after activation of synaptic glutamate receptors.
    1. Neuroscience

    Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons

    Farid N Garas et al.
    In rodents and primates, there are two subtypes of parvalbumin-expressing interneurons that provide novel substrates for selective inhibition in the striatum.
    1. Evolutionary Biology

    The genetic architecture of gene expression levels in wild baboons

    Jenny Tung et al.
    RNA sequencing of individuals within a wild baboon population reveals extensive power to detect functional regulatory variation, and suggests that the set of genes affected by such variation may be conserved across species.
    1. Neuroscience

    Dipolar extracellular potentials generated by axonal projections

    Thomas McColgan et al.
    Action potentials propagating in axon bundles with bifurcating and terminating fibers cause strong and far-reaching extracellular potentials.
    1. Neuroscience

    Developmental 'awakening' of primary motor cortex to the sensory consequences of movement

    James C Dooley, Mark S Blumberg
    Early in development, before neurons in primary motor cortex are involved in motor control, they undergo a rapid transition in how they process sensory information following sleep and wake movements.
    1. Cell Biology

    The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

    Tsui Han Loo et al.
    The LINC complex, that couples the interphase cytoskeleton to the nucleus, regulates the processing of a cluster of miRNAs required for muscle regeneration by recruiting and interacting directly with Drosha.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection

    Magdalena Steinrueck, Călin C Guet
    Experimental evolution reveals how adaptation by increased expression of a gene depends on a combination of simple genetic properties of the gene's neighbors on the DNA.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression

    Trever T Greene et al.
    Viral infection can induce NKG2D ligand expression through the action of virally encoded histone deacetylase (HDAC) inhibitors, which release HDAC mediated repression of NKG2D ligands.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Overall energy conversion efficiency of a photosynthetic vesicle

    Melih Sener et al.
    The overall energy conversion efficiency is calculated for a bacterial vesicle that harvests solar energy for ATP production on the basis of an atomic-detail structural model.