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    1. Physics of Living Systems
    2. Immunology and Inflammation

    Early life imprints the hierarchy of T cell clone sizes

    Mario U Gaimann, Maximilian Nguyen ... Andreas Mayer
    The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

    William S DeWitt III, Anajane Smith ... Philip Bradley
    An analysis of T cell receptor occurrence patterns that accounts for MHC restriction reveals striking imprints of common viral pathogens and patterns of TCR-HLA sequence covariation in a large human cohort.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching

    Felix Horns, Christopher Vollmers ... Stephen R Quake
    A comprehensive map of patterns of class switching reveals how antibodies of every class are created in humans.
    1. Immunology and Inflammation

    Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens

    Valentin Quiniou, Pierre Barennes ... David Klatzmann
    The thymic selection of the human T-cell receptor repertoire releases polyspecific receptors with the ability to recognize and respond to peptides from unrelated viruses.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Combining mutation and recombination statistics to infer clonal families in antibody repertoires

    Natanael Spisak, Gabriel Athènes ... Aleksandra M Walczak
    HILARy is a new algorithm for grouping B-cell receptor sequences into distinct lineages, a crucial task to analyze immune response and memory through repertoire sequencing.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

    Peter C de Greef, Theres Oakes ... Rob J de Boer
    Combining experiments, bioinformatics, and mathematical modelling, we find large heterogeneity in naive T cell clone sizes.
    1. Immunology and Inflammation

    Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

    Magdalena L Russell, Aisha Souquette ... Philip Bradley
    Trans genetic variation in TdT and Artemis loci impacts V(D)J recombination probabilities.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Deep generative models for T cell receptor protein sequences

    Kristian Davidsen, Branden J Olson ... Frederick A Matsen IV
    Deep learning improves estimation of T cell receptor cohort frequencies and learns the rules of VDJ recombination, potentially making it helpful for vaccine design.
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